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KMID : 1137020150260040284
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Journal of Gynecologic Oncology
2015 Volume.26 No. 4 p.284 ~ p.292
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Adjuvant sequential chemo and radiotherapy improves the oncological outcome in high risk endometrial cancer
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Signorelli Mauro
Lissoni Andrea Alberto
De Ponti Elena
Grassi Tommaso
Ponti Serena
Fruscio Robert
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Abstract
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Objective: Evaluation of the impact of sequential chemoradiotherapy in high risk endometrial cancer (EC).
Methods: Two hundred fifty-four women with stage IB grade 3, II and III EC (2009 FIGO staging), were included in this retrospective study.
Results: Stage I, II, and III was 24%, 28.7%, and 47.3%, respectively. Grade 3 tumor was 53.2% and 71.3% had deep myometrial invasion. One hundred sixty-five women (65%) underwent pelvic (+/- aortic) lymphadenectomy and 58 (22.8%) had nodal metastases. Ninety-eight women (38.6%) underwent radiotherapy, 59 (23.2%) chemotherapy, 42 (16.5%) sequential chemoradiotherapy, and 55 (21.7%) were only observed. After a median follow-up of 101 months, 78 women (30.7%) relapsed and 91 women (35.8%) died. Sequential chemoradiotherapy improved survival rates in women who did not undergo nodal evaluation (disease-free survival [DFS], p=0.040; overall survival [OS], p=0.024) or pelvic (+/- aortic) lymphadenectomy (DFS, p=0.008; OS, p=0.021). Sequential chemoradiotherapy improved both DFS (p=0.015) and OS (p=0.014) in stage III, while only a trend was found for DFS (p=0.210) and OS (p=0.102) in stage I-II EC. In the multivariate analysis, only age (≤65 years) and sequential chemoradiotherapy were statistically related to the prognosis.
Conclusion: Sequential chemoradiotherapy improves survival rates in high risk EC compared with chemotherapy or radiotherapy alone, in particular in stage III.
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KEYWORD
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Endometrial Neoplasms, Lymph Node Excision, Multivariate Analysis, Retrospective Studies, Survival rate
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